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WHY THIS MATTERS IN BRIEF

Today medicines are all too often in common sized dosages with standard formulations, irrespective of our age or size, but 3D printing allows us to customise both and tailor medicines to the individual.

 

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FabRx, a British company that uses 3D printing to print personalised medicines and pharmaceuticals, which not only means pharmacies and hospitals can do away with their complex supply chains but also means patients get precisely the doses they need, has developed personalized medicine for children with the rare metabolic disorder, Maple Syrup Urine Disease (MSUD).

 

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As a life long condition MSUD requires patientspecific therapies and supplements, which are currently provided manually by healthcare providers. FabRx’s 3D printed chewable tablets, called the Printlets, now mean that these providers have a rapid and automated alternative for the preparation of tailored therapeutic dosages.

A human clinical study on the Printlets has been completed between researchers from University College London (UCL), University of Santiago de Compostela (USC), Spain, and the Clinic University Hospital in Santiago de Compostela. Results show that the Printlets have similar effectiveness but higher patient acceptability compared to conventional treatments.

 

The Printlets

Working at UCL’s Advanced 3D Printing Lab, FabRx has been conducting research surrounding 3D printed medicines for more than 5 years on the principle that everyone is different and needs personal patient care. At present, the company employs four different 3D printing methods – SLA, SLS, FFF, and Semi-Solid Extrusion – to medicinal development.

 

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Pill models at the company include its trademark Printlets technology – tablets 3D printed to contain specific dosages of a drug in a variety of shapes and sizes, making them easier to swallow. Earlier this year, the company received a £650,000 grant from Innovate UK to develop their 3D printing system further.

According to Patient UK MSUD has a worldwide prevalence of 1 in every 185,000 live births. The first line of therapy for MSUD involves a strict diet and amino acid supplements from isoleucine and valine. The dose administered to patients requires strict tailoring according to age, weight and blood concentration of isoleucine.

In current clinical practice, practitioners still have to manually prepare formulations in order to provide patients with the specified doses which is time-consuming and costly. With the aim of improving safety and acceptability to isoleucine supplementation in paediatric MSUD patients (aged 3 – 16 years), the research team decided to use 3D printing for preparing personalized therapies.

 

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“There is a real need for new manufacturing systems to prepare personalised medicines. The potential application of the 3D printing for rare diseases are countless and it could help to make the medicines safer and more attractive to children,” stated Maria-Luz Couce, Head of the Paediatrics Section of the Clinical University Hospital concluded.

FabRx’s 3D printing system can make Printlets with up to 6 different drugs, where each drug is represented as a different color. Compared to forming capsules by manual compounding, 3D printing the chewable formulations is faster and allows the preparation of one month’s therapy – 28 printlets – to be completed in less than 8 minutes.

After 6 months of monitoring MSUD patients, the results showed that the personalized Printlets were as effective as the conventional medication in controlling the patients’ blood levels of isoleucine. Furthermore, isoleucine blood concentrations were closer to the isoleucine target value with less variation for the patients receiving the Printlets treatment. The ability of the 3D printing system to create Printlets with different colors and flavors had a further positive impact in enhancing patients’ acceptability of the treatment.

“Automated therapy preparation of isoleucine formulations using 3D printing for the treatment of MSUD: First single-centre, prospective, crossover study in patients” is published in the International Journal of Pharmaceutics.

About author

Matthew Griffin

Matthew Griffin, described as “The Adviser behind the Advisers” and a “Young Kurzweil,” is the founder and CEO of the World Futures Forum and the 311 Institute, a global Futures and Deep Futures consultancy working between the dates of 2020 to 2070, and is an award winning futurist, and author of “Codex of the Future” series. Regularly featured in the global media, including AP, BBC, Bloomberg, CNBC, Discovery, RT, Viacom, and WIRED, Matthew’s ability to identify, track, and explain the impacts of hundreds of revolutionary emerging technologies on global culture, industry and society, is unparalleled. Recognised for the past six years as one of the world’s foremost futurists, innovation and strategy experts Matthew is an international speaker who helps governments, investors, multi-nationals and regulators around the world envision, build and lead an inclusive, sustainable future. A rare talent Matthew’s recent work includes mentoring Lunar XPrize teams, re-envisioning global education and training with the G20, and helping the world’s largest organisations envision and ideate the future of their products and services, industries, and countries. Matthew's clients include three Prime Ministers and several governments, including the G7, Accenture, Aon, Bain & Co, BCG, Credit Suisse, Dell EMC, Dentons, Deloitte, E&Y, GEMS, Huawei, JPMorgan Chase, KPMG, Lego, McKinsey, PWC, Qualcomm, SAP, Samsung, Sopra Steria, T-Mobile, and many more.

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