WHY THIS MATTERS IN BRIEF
If it reaches humans, injectable nanorobotics could speed recovery from spinal injuries long considered untreatable.
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Despite significant medical advances, spinal cord damage which often leads to Paralysis remains one of the most difficult physical injuries to treat. Scarring frequently gets in the way of nerve fibre regrowth, while nerve cells usually cannot regenerate on their own. A possible solution? A fleet of stem cell infused, injectable nanorobots that can help nerve cells regenerate. The tiny bots are detailed in a study recently published in the journal .
To build their new tools, a team at ETH Zurich in Switzerland engineered microscopic machines that combine living neural progenitor cells (NPCs) – specialised stem cells developed for the spine – with customised nanoparticles. These customised nanoparticles feature two layers – one that is sensitive to magnetic fields and another that translates them into electrical signals.
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“We place a reservoir in the centre where we trap the cells. Then we inject the nanoparticles and wait for the two components to bind,” , a study co-author and ETH Zurich roboticist, .
Each nanorobot is about six micrometers wide, making them smaller than a red blood cell. However, the number of robots required to pull off a procedure is immense. Millions of nanobots are needed during animal trials. Even with such a high number, the initial experimental results are promising. In tests involving mice with severed spinal cords, nerve cells stimulated by the microrobots began reconnecting at the injury site within 28 days. By the end of the trial, the mice displayed major improvements in movement, gait, coordination, and exploratory behaviour.
Significantly more research is required before these nanobots are ready for primetime, but the team hopes to one day begin testing similar devices in humans. Before that, they need to determine the most effective magnetic fields and how long to apply them to patients. In the meantime, the overall design could also be applied to help treat regenerative issues in organs and wounds.
“The reproducible and scalable production of microrobots using our Lab-on-a-Chip system demonstrates that the platform’s application potential extends beyond basic research,” added Pané i Vidal.
How close is this to treating people?
Still early — the results come from mice, and researchers must first refine the magnetic controls and safety before any human trials of the injectable nanorobots can begin.















