It seems algorithms rule the world, now scientists think they have identified the algorithm responsible for human intelligence, if true then it could revolutionise artificial intelligence.


Little might you realise but as you read this article there’s a good chance your brain is running its “n=2ⁱ-1” algorithm – and you thought you were rubbish at maths!

Scientists in the USA now believe that our brains have a basic algorithm that enable us to not just recognise a meal, or words on a page, for example, but also the intelligence to ponder their broader implications.

“A relatively simple mathematical logic underlies our complex brain computations,” said Dr. Joe Tsien, a neuroscientist at the Medical College of Georgia at Augusta University.

Tsien is talking about his Theory of Connectivity, a fundamental principle for how our billions of neurons assemble and align not just to acquire knowledge, but to generalise and draw conclusions from it.


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“Intelligence is really about dealing with uncertainty and infinite possibilities,” said Tsien, “it appears to be enabled when a group of similar neurons form a variety of cliques to handle each basic like recognising food, shelter, friends and foes. Groups of cliques then cluster into functional connectivity motifs, or FCMs, to handle every possibility in each of these basics like extrapolating that rice is part of an important food group that might be a good side dish for your meal. The more complex the thought, the more cliques join in.”

That means, for example, we cannot only recognise an office chair, but an office when we see one and know that the chair is where we sit in that office.

“You know an office is an office whether it’s at your house or the White House,” Tsien said of the ability to conceptualize knowledge – which is one of many things that distinguishes us from computers.

Now, for the first time, Tsien and his colleagues have documented the algorithm at work in seven different brain regions involved with those basics like food and fear in mice and hamsters. Their documentation is published in the journal Frontiers in Systems Neuroscience.

“For it to be a universal principle, it needs to be operating in many neural circuits, so we selected seven different brain regions and, surprisingly, we indeed saw this principle operating in all these regions,” he said.

Intricate organisation seems plausible, even essential, in a human brain, which has about 86 billion neurons and where each neuron can have tens of thousands of synapses, putting potential connections and communications between neurons into the trillions. On top of the seemingly endless connections is the reality of the infinite number of things that each of us can experience and learn.


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Neuroscientists as well as computer experts have long been curious about how the brain is able to not only hold specific information, like a computer, but – unlike even the most sophisticated technology – to also categorise and generalise the information into abstract knowledge and concepts.

“Many people have long speculated that there has to be a basic design principle from which intelligence originates and the brain evolves, like how the double helix of DNA and genetic codes are universal for every organism,” Tsien said, “we have presented evidence that the brain may operate on an amazingly simple mathematical logic.”

“In my view, Joe Tsien proposes an interesting idea that proposes a simple organisational principle of the brain, and that is supported by intriguing and suggestive evidence,” said Dr. Thomas Südhof, a neuroscientist studying synapse formation and function and a winner of the 2013 Nobel Prize in Physiology and Medicine at the Stanford University School of Medicine.

“This idea is very much worth testing further,” said Südhof, a sentiment echoed by Tsien and his colleagues, “and it needs to be tested in additional neural circuits as well as other animal species and artificial intelligence systems.”

At the heart of Tsien’s Theory of Connectivity is the algorithm, n=2ⁱ-1, which defines how many cliques are needed for an FCM and which enabled the scientists to predict the number of cliques needed to recognise food options during their tests. N is the number of neural cliques connected in different possible ways, 2 means the neurons in those cliques are receiving the input or not, meanwhile i is the information they are receiving and -1 is just part of the math that enables you to account for all possibilities, Tsien explained. To test the theory, they placed electrodes in specific areas of the brain so they could “listen” to the response of neurons, or their action potential, and examine the unique waveforms resulting from each. They gave the animals, for example, different combinations of four different foods, such as usual rodent biscuits as well as sugar pellets, rice and milk, and as the Theory of Connectivity would predict, the scientists could identify all 15 different cliques, or groupings of neurons, that responded to the potential variety of food combinations.


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The neuronal cliques appear prewired during brain development because they showed up immediately when the food choices did. The fundamental mathematical rule even remained largely intact when the NMDA receptor, a master switch for learning and memory, was disabled after the brain matured.

The scientists also learned that size matters, because while human and animal brains both have a six layered cerebral cortex – the lumpy outer layer of the brain that plays a key role in higher brain functions like learning and memory – the extra longitudinal length of the human cortex provides more room for cliques and FCMs, Tsien said. And while the overall girth of the elephant brain is definitely larger than the human brain, for example, most of its neurons reside in the cerebellum with far less in their super-sized cerebral cortex. The cerebellum is more involved in muscle coordination, which may help explain the agility of the huge mammal, particularly its trunk.

About author

Matthew Griffin

Matthew Griffin, described as “The Adviser behind the Advisers” and a “Young Kurzweil,” is the founder and CEO of the World Futures Forum and the 311 Institute, a global Futures and Deep Futures consultancy working between the dates of 2020 to 2070, and is an award winning futurist, and author of “Codex of the Future” series. Regularly featured in the global media, including AP, BBC, Bloomberg, CNBC, Discovery, RT, Viacom, and WIRED, Matthew’s ability to identify, track, and explain the impacts of hundreds of revolutionary emerging technologies on global culture, industry and society, is unparalleled. Recognised for the past six years as one of the world’s foremost futurists, innovation and strategy experts Matthew is an international speaker who helps governments, investors, multi-nationals and regulators around the world envision, build and lead an inclusive, sustainable future. A rare talent Matthew’s recent work includes mentoring Lunar XPrize teams, re-envisioning global education and training with the G20, and helping the world’s largest organisations envision and ideate the future of their products and services, industries, and countries. Matthew's clients include three Prime Ministers and several governments, including the G7, Accenture, Aon, Bain & Co, BCG, Credit Suisse, Dell EMC, Dentons, Deloitte, E&Y, GEMS, Huawei, JPMorgan Chase, KPMG, Lego, McKinsey, PWC, Qualcomm, SAP, Samsung, Sopra Steria, T-Mobile, and many more.

  • David D’Souza#1

    28th November 2016

    Matthew – It must be a basic chemical construct that leads to electrical activity. An enhanced chemical construct that leads to hyper electrical activity or super intelligence. But there must be a threshold that never gets breached because statistically we should be producing more geniuses in the population by now. Rather, the idiot population is rising ..

    • Rohit#2

      22nd December 2016

      You are true with respect to your last sentence. Or may be perhaps the geniuses are not getting proper recognition. Or the general population is ignoring scientific knowledge and getting swooped by trivial phenomena caused by religion, politics or materialism.

  • Brad#3

    28th November 2016

    I think this is the point where we all go back and read Baudrillard’s comments in Simulations about human’s disappearing into the “code” DNA.


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