Matthew Griffin, described as “The Adviser behind the Advisers” and a “Young Kurzweil,” is the founder and CEO of the World Futures Forum and the 311 Institute, a global Futures and Deep Futures consultancy working between the dates of 2020 to 2070, and is an award winning futurist, and author of “Codex of the Future” series. Regularly featured in the global media, including AP, BBC, Bloomberg, CNBC, Discovery, RT, Viacom, and WIRED, Matthew’s ability to identify, track, and explain the impacts of hundreds of revolutionary emerging technologies on global culture, industry and society, is unparalleled. Recognised for the past six years as one of the world’s foremost futurists, innovation and strategy experts Matthew is an international speaker who helps governments, investors, multi-nationals and regulators around the world envision, build and lead an inclusive, sustainable future. A rare talent Matthew’s recent work includes mentoring Lunar XPrize teams, re-envisioning global education and training with the G20, and helping the world’s largest organisations envision and ideate the future of their products and services, industries, and countries. Matthew's clients include three Prime Ministers and several governments, including the G7, Accenture, Aon, Bain & Co, BCG, Credit Suisse, Dell EMC, Dentons, Deloitte, E&Y, GEMS, Huawei, JPMorgan Chase, KPMG, Lego, McKinsey, PWC, Qualcomm, SAP, Samsung, Sopra Steria, T-Mobile, and many more.
WHY THIS MATTERS IN BRIEF
The ability to sequence the whole genome of patients and identify “genomic events” that lead to cancer development could be revolutionary.
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Recently doctors in the US announced they’d finally managed to sequence the entire human genome in under 5 hours. Not only was this revolutionary in its own right, but as gene sequencing gets better, faster, and cheaper it opens the door to all manner of personalised healthcare treatments some of which, as we’ve seeing already, have already been successfully been used to treat certain Stage 3 and Stage 4 cancers with 100% success rates.
Now, a few months on a study into the benefits of whole genome sequencing makes the case for more extensive gene mapping in disease research, in this case with whole genome sequencing offering an unprecedented look at the makeup and behavior of Hodgkin Lymphoma which, in time, could lead to better understanding of this and other cancers’ development and treatment.
The Future of Work and Healthcare, by keynote Matthew Griffin
The current standard exome sequencing, which is a detailed look at protein-coding genes, detects some mutations and variants that advance cancers. But researchers at Sylvester Comprehensive Cancer Center in the University of Miami Miller School of Medicine found that whole-genome sequencing paints a bigger, broader picture and detects other changes related to cancer development.
The study also noted that whole genome sequencing identified other key events such as chromothripsis, the chromosomal rearrangement that plays a role in many cancers.
“We found that, by using whole genome sequencing, we can read virtually all the mutations in both protein coding and noncoding regions of the genome, as well as structural and copy number variations,” said Dr Craig Moskowitz co-author on the study. “We found many genomic events that had never been recorded before. It’s the best technology we’ve found to identify new cancer drivers.”
The team’s research, published in journal Blood Cancer Discovery, involved the creation of a sorting system to isolate and enlarge the difficult-to-study and rare Hodgkin and Reed Sternberg (cHL) cells, the hallmarks of the lymphatic system cancer. The research on these abnormal white blood cells, when combined with whole genome sequencing, will provide the scientists with the template to now take a similar, more detailed look at other cancers.
“Cancers are incredibly complex diseases, and we still have a long way to go before we fully understand them,” said Dr C. Ola Landgren the other co-author on the study. “By leveraging whole genome sequencing, we can better assess tumor evolution, identify structural issues, and hopefully gain new therapeutic insights.”
This comes after news that National Institutes of Health has developed an innovative software tool that can assemble a whole genome sequence in just days. Verkko as it’s called was created by the Telomere-to-Telomere (T2T) consortium, the collaborative project funded by NIH’s National Human Genome Research Institute (NHGRI) that was behind the world’s first complete human genome sequenced in 2022.
“We took everything we learned in the T2T project and automated the process,” said NHGRI associate investigator Sergey Koren, who spearheaded the Verkko project and is senior author on the paper. “Now with Verkko, we can essentially push a button and automatically get a complete genome sequence.”
It took two decades to shift the needle from 92% to 100% in human genome mapping, following on from the Human Genome Project’s ambitious plan to ID more than three billion base pairs that form DNA, and nearly three years for the T2T consortium to manually assemble the difficult final fragments to complete the very first gapless genome. Now, Verkko can complete the task in just days.
“Verkko can democratize generating gapless genome sequences,” said Adam Phillippy, an NHGRI senior investigator who worked on the T2T project and Verkko. “This new software will make assembling complete genome sequences as affordable and routine as possible.”
Newly mapped regions of the human genome are likely to lead to much better understanding and in turn treatment of disease. Scientists also hope Verkko will speed up efforts to map complete genomes of common research species such as mice, fruit flies and zebrafish, in an effort to better understand these complementary animals. Mapping species further afield will also aid in comparative genomics, and potentially lead to new genetic links between seemingly diverse species.